Mechanism of PARP inhibitor resistance and potential overcoming strategies

Mechanism of PARP inhibitor resistance and potential overcoming strategies

PARP inhibitors (PARPi) are a kind of cancer therapy that targets poly (ADP-ribose) polymerase. PARPi is the first clinically approved drug to exert synthetic lethality by obstructing the DNA single-strand break repair process. Despite the significant therapeutic effect in patients with homologous r...

Full description

Bibliographic Details
Main Authors: Xiaoyu Fu, Ping Li, Qi Zhou, Ruyuan He, Guannan Wang, Shiya Zhu, Amir Bagheri, Gary Kupfer, Huadong Pei, Juanjuan Li
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-01-01
Series:Genes and Diseases
Subjects:
Drug resistance
Homologous recombination
PARP
PARP inhibitor
Poly (ADP-ribose) polymerase
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304223000661

Internet

http://www.sciencedirect.com/science/article/pii/S2352304223000661

Similar Items