Acetonitrile Adducts of Tranexamic Acid as Sensitive Ions for Quantification at Residue Levels in Human Plasma by UHPLC-MS/MS

Acetonitrile Adducts of Tranexamic Acid as Sensitive Ions for Quantification at Residue Levels in Human Plasma by UHPLC-MS/MS

The quantitative analysis of pharmaceuticals in biomatrices by liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) is often hampered by adduct formation. The use of the molecular ion resulting from solvent adducts for quantification is uncommon, even if...

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Bibliographic Details
Main Authors: Eduarda M. P. Silva, Luisa Barreiros, Sara R. Fernandes, Paula Sá, João P. Prates Ramalho, Marcela A. Segundo
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Pharmaceuticals
Subjects:
electrospray ionization
collision-induced dissociation
fragmentation
solvent adducts
analyte quantification
Online Access:https://www.mdpi.com/1424-8247/14/12/1205

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https://www.mdpi.com/1424-8247/14/12/1205

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