African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans

African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans

Abstract Background Asthma is the most common chronic disease in children, occurring at higher frequencies and with more severe disease in children with African ancestry. Methods We tested for association with haplotypes at the most replicated and significant childhood-onset asthma locus at 17q12-q2...

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Bibliographic Details
Main Authors: Charles Washington, Matthew Dapas, Arjun Biddanda, Kevin M. Magnaye, Ivy Aneas, Britney A. Helling, Brooke Szczesny, Meher Preethi Boorgula, Margaret A. Taub, Eimear Kenny, Rasika A. Mathias, Kathleen C. Barnes, CAAPA, Gurjit K. Khurana Hershey, Carolyn M. Kercsmar, Jessica D. Gereige, Melanie Makhija, Rebecca S. Gruchalla, Michelle A. Gill, Andrew H. Liu, Deepa Rastogi, William Busse, Peter J. Gergen, Cynthia M. Visness, Diane R. Gold, Tina Hartert, Christine C. Johnson, Robert F. Lemanske, Fernando D. Martinez, Rachel L. Miller, Dennis Ownby, Christine M. Seroogy, Anne L. Wright, Edward M. Zoratti, Leonard B. Bacharier, Meyer Kattan, George T. O’Connor, Robert A. Wood, Marcelo A. Nobrega, Matthew C. Altman, Daniel J. Jackson, James E. Gern, Christopher G. McKennan, Carole Ober
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Genome Medicine
Subjects:
Asthma
Fine mapping
Integrated omics
Whole-genome sequencing
Health disparities
Online Access:https://doi.org/10.1186/s13073-022-01114-x

Internet

https://doi.org/10.1186/s13073-022-01114-x

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