Phosphodiesterase type 10A inhibitor attenuates lung fibrosis by targeting myofibroblast activation

Phosphodiesterase type 10A inhibitor attenuates lung fibrosis by targeting myofibroblast activation

Summary: Pulmonary fibrosis (PF) is a fatal and irreversible respiratory disease accompanied by excessive fibroblast activation. Previous studies have suggested that cAMP signaling pathway and cGMP-PKG signaling pathway are continuously down-regulated in lung fibrosis, whereas PDE10A has a specifica...

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Bibliographic Details
Main Authors: Ya-Jun Li, Jian-Rong Shi, Shu-Chan Li, Lu-Ming Wang, Rana Dhar, Ning Li, Xin-Wei Cao, Zi-Gang Li, Hui-Fang Tang
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:iScience
Subjects:
Pharmacology
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223006636

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http://www.sciencedirect.com/science/article/pii/S2589004223006636

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