Aldehyde Dehydrogenase, a Therapeutic Target in Chordoma: Analysis in 3D Cellular Models

Aldehyde Dehydrogenase, a Therapeutic Target in Chordoma: Analysis in 3D Cellular Models

Chordomas are rare, slow-growing tumors of the axial skeleton. These tumors are locally aggressive and refractory to conventional therapies. Radical surgery and radiation remain the first-line treatments. Despite these aggressive treatments, chordomas often recur and second-line treatment options ar...

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Bibliographic Details
Main Authors: Marie-Anaïs Locquet, Anne-Lise Dechaume, Paul Berchard, Lhorra Abbes, Daniel Pissaloux, Franck Tirode, Inès Ramos, Julie Bedoucha, Julie Valantin, Marie Karanian, Raul Perret, Olivier Gille, Jean-Yves Blay, Aurélie Dutour
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cells
Subjects:
chordoma
3D models
hypoxia
radiotherapy
aldehyde dehydrogenase
radioresistance
Online Access:https://www.mdpi.com/2073-4409/10/2/399

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https://www.mdpi.com/2073-4409/10/2/399

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