Loss of the Extracellular Matrix Molecule Tenascin-C Leads to Absence of Reactive Gliosis and Promotes Anti-inflammatory Cytokine Expression in an Autoimmune Glaucoma Mouse Model

Loss of the Extracellular Matrix Molecule Tenascin-C Leads to Absence of Reactive Gliosis and Promotes Anti-inflammatory Cytokine Expression in an Autoimmune Glaucoma Mouse Model

Previous studies demonstrated that retinal damage correlates with a massive remodeling of extracellular matrix (ECM) molecules and reactive gliosis. However, the functional significance of the ECM in retinal neurodegeneration is still unknown. In the present study, we used an intraocular pressure (I...

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Bibliographic Details
Main Authors: Susanne Wiemann, Jacqueline Reinhard, Sabrina Reinehr, Zülal Cibir, Stephanie C. Joachim, Andreas Faissner
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
autoimmune glaucoma model
cytokines
microglia
optic nerve demyelination
reactive gliosis
tenascin-C
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.566279/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.566279/full

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