Behavioral and neuro-functional consequences of eliminating the KCNQ3 GABA binding site in mice

Behavioral and neuro-functional consequences of eliminating the KCNQ3 GABA binding site in mice

Voltage-gated potassium (Kv) channels formed by α subunits KCNQ2-5 are important in regulating neuronal excitability. We previously found that GABA directly binds to and activates channels containing KCNQ3, challenging the traditional understanding of inhibitory neurotransmission. To investigate the...

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Bibliographic Details
Main Authors: Kiki J. Chen, Ryan Yoshimura, Clarissa Adriana Edmundo, Tri Minh Truong, Olivier Civelli, Amal Alachkar, Geoffrey W. Abbott
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
KCNQ3
GABA
binding
behaviors
mutation
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1192628/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1192628/full

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