Anaplastic transformation in thyroid cancer revealed by single-cell transcriptomics

Anaplastic transformation in thyroid cancer revealed by single-cell transcriptomics

The deadliest anaplastic thyroid cancer (ATC) often transforms from indolent differentiated thyroid cancer (DTC); however, the complex intratumor transformation process is poorly understood. We investigated an anaplastic transformation model by dissecting both cell lineage and cell fate transitions...

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Bibliographic Details
Main Authors: Lina Lu, Jennifer Rui Wang, Ying C. Henderson, Shanshan Bai, Jie Yang, Min Hu, Cheng-Kai Shiau, Timothy Pan, Yuanqing Yan, Tuan M. Tran, Jianzhuo Li, Rachel Kieser, Xiao Zhao, Jiping Wang, Roza Nurieva, Michelle D. Williams, Maria E. Cabanillas, Ramona Dadu, Naifa Lamki Busaidy, Mark Zafereo, Nicholas Navin, Stephen Y. Lai, Ruli Gao
Format: Article
Language:English
Published: American Society for Clinical Investigation 2023-06-01
Series:The Journal of Clinical Investigation
Subjects:
Genetics
Oncology
Online Access:https://doi.org/10.1172/JCI169653

Internet

https://doi.org/10.1172/JCI169653

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