Chronic pain in adults with sickle cell disease is associated with alterations in functional connectivity of the brain.

Chronic pain affects 50% of adults with sickle cell disease (SCD). Although central sensitization is thought to contribute to the pathogenesis of this chronic pain, no studies have examined differences in functional connectivity of the brain between patients with SCD with and without chronic pain. W...

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Bibliographic Details
Main Authors: Matthew S Karafin, Guangyu Chen, Nancy J Wandersee, Amanda M Brandow, Robert W Hurley, Pippa Simpson, Doug Ward, Shi-Jiang Li, Joshua J Field
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0216994