Plasma cortisol-linked gene networks in hepatic and adipose tissues implicate corticosteroid-binding globulin in modulating tissue glucocorticoid action and cardiovascular risk

Plasma cortisol-linked gene networks in hepatic and adipose tissues implicate corticosteroid-binding globulin in modulating tissue glucocorticoid action and cardiovascular risk

Genome-wide association meta-analysis (GWAMA) by the Cortisol Network (CORNET) consortium identified genetic variants spanning the SERPINA6/SERPINA1 locus on chromosome 14 associated with morning plasma cortisol, cardiovascular disease (CVD), and SERPINA6 mRNA expression encoding corticosteroid-bind...

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Bibliographic Details
Main Authors: Sean Bankier, Lingfei Wang, Andrew Crawford, Ruth A. Morgan, Arno Ruusalepp, Ruth Andrew, Johan L. M. Björkegren, Brian R. Walker, Tom Michoel
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Endocrinology
Subjects:
cortisol
corticosteroid-binding globulin
gene networks
systems genetics
causal inference
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1186252/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1186252/full

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