The Impact of O6-Methylguanine-DNA Methyltransferase (<i>MGMT</i>) Promoter Methylation on the Outcomes of Patients with Leiomyosarcoma Treated with Dacarbazine

The Impact of O6-Methylguanine-DNA Methyltransferase (<i>MGMT</i>) Promoter Methylation on the Outcomes of Patients with Leiomyosarcoma Treated with Dacarbazine

Dacarbazine is an important drug in the therapeutic landscape of leiomyosarcoma (LMS). Alkylating agents are subjected to resistance mechanisms based on anti-apoptotic pathways and repair mechanisms, including the DNA repair enzyme O6-methylguanine-DNA methyltransferase (<i>MGMT</i>). In...

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Bibliographic Details
Main Authors: Lucia Cannella, Rosa Della Monica, Antonella Lucia Marretta, Domenico Iervolino, Bruno Vincenzi, Anna Rosaria De Chiara, Ottavia Clemente, Michela Buonaiuto, Maria Luisa Barretta, Annabella Di Mauro, Massimiliano Di Marzo, Michele Guida, Giuseppe Badalamenti, Lorenzo Chiariotti, Salvatore Tafuto
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cells
Subjects:
leiomyosarcoma
soft-tissue tumor
dacarbazine
O6-methylguanine-DNA methyltransferase
<i>MGMT</i>
Online Access:https://www.mdpi.com/2073-4409/12/12/1635

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https://www.mdpi.com/2073-4409/12/12/1635

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