The implication of targeting PD-1:PD-L1 pathway in treating sepsis through immunostimulatory and anti-inflammatory pathways

The implication of targeting PD-1:PD-L1 pathway in treating sepsis through immunostimulatory and anti-inflammatory pathways

Sepsis currently remains a major contributor to mortality in the intensive care unit (ICU), with 48.9 million cases reported globally and a mortality rate of 22.5% in 2017, accounting for almost 20% of all-cause mortality worldwide. This highlights the urgent need to improve the understanding and tr...

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Bibliographic Details
Main Authors: Yu Chen, De-zhi Guo, Cheng-long Zhu, Shi-chun Ren, Chen-yan Sun, Yi Wang, Jia-feng Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Immunology
Subjects:
sepsis
PD-1/PD-L1
immune homeostasis
immunoparalysis
organ damage
treatment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1323797/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1323797/full

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