Neuronal-Specific Inhibition of Endoplasmic Reticulum Mg<sup>2+</sup>/Ca<sup>2+</sup> ATPase Ca<sup>2+</sup> Uptake in a Mixed Primary Hippocampal Culture Model of Status Epilepticus

Neuronal-Specific Inhibition of Endoplasmic Reticulum Mg<sup>2+</sup>/Ca<sup>2+</sup> ATPase Ca<sup>2+</sup> Uptake in a Mixed Primary Hippocampal Culture Model of Status Epilepticus

Loss of intracellular calcium homeostasis is an established mechanism associated with neuronal dysfunction and status epilepticus. Sequestration of free cytosolic calcium into endoplasmic reticulum by Mg<sup>2+</sup>/Ca<sup>2+</sup> adenosinetriphosphatase (ATPase) is critica...

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Bibliographic Details
Main Authors: Laxmikant S. Deshpande, Robert J. DeLorenzo, Severn B. Churn, J. Travis Parsons
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Brain Sciences
Subjects:
seizure
epilepsy
SERCA
NMDA
glia
calcium homeostasis
Online Access:https://www.mdpi.com/2076-3425/10/7/438

Internet

https://www.mdpi.com/2076-3425/10/7/438

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