Pituitary adenylyl cyclase activating polypeptide inhibits <it>gli1 </it>gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures

Pituitary adenylyl cyclase activating polypeptide inhibits <it>gli1 </it>gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures

<p>Abstract</p> <p>Background</p> <p>Hedgehog (HH) signaling is critical for the expansion of granule neuron precursors (GNPs) within the external granular layer (EGL) during cerebellar development. Aberrant HH signaling within GNPs is thought to give rise to medullobla...

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Bibliographic Details
Main Authors: Dong Hongmei, Niewiadomski Pawel, Resnick Daniel Z, Cohen Joseph R, Liau Linda M, Waschek James A
Format: Article
Language:English
Published: BMC 2010-12-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/10/676

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http://www.biomedcentral.com/1471-2407/10/676

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