Folate-Targeted Monodisperse PEG-Based Conjugates Made by Chemo-Enzymatic Methods for Cancer Diagnosis and Treatment

Folate-Targeted Monodisperse PEG-Based Conjugates Made by Chemo-Enzymatic Methods for Cancer Diagnosis and Treatment

This paper focuses on preliminary in vitro and in vivo testing of new bivalent folate-targeted PEGylated doxorubicin (DOX) made by modular chemo-enzymatic processes (FA<sub>2</sub>-dPEG-DOX<sub>2</sub>). A unique feature is the use of monodisperse PEG (dPEG). The modular appr...

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Bibliographic Details
Main Authors: Krisztina S. Nagy, Krisztina Toth, Eva Pallinger, Angela Takacs, Laszlo Kohidai, Angela Jedlovszky-Hajdu, Domokos Mathe, Noemi Kovacs, Daniel S. Veres, Krisztian Szigeti, Kristof Molnar, Eniko Krisch, Judit E. Puskas
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
folate-targeted cancer diagnosis
polymer conjugates
multivalency
chemo-enzymatic synthesis
in vitro screening
in vivo screening
Online Access:https://www.mdpi.com/1422-0067/22/19/10347

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https://www.mdpi.com/1422-0067/22/19/10347

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