The abundance of the short GATA1 isoform affects megakaryocyte differentiation and leukemic predisposition in mice
Abstract Transcription factor GATA1 controls the delicate balance between proliferation, differentiation and apoptosis in both the erythroid and megakaryocytic lineages. In addition to full-length GATA1, there is an GATA1 isoform, GATA1s, that lacks the amino-terminal transactivation domain. Somatic...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-02-01
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| Series: | Experimental Hematology & Oncology |
| Online Access: | https://doi.org/10.1186/s40164-024-00492-9 |