Establishment of UGT1A1-knockout human iPS-derived hepatic organoids for UGT1A1-specific kinetics and toxicity evaluation

Establishment of UGT1A1-knockout human iPS-derived hepatic organoids for UGT1A1-specific kinetics and toxicity evaluation

Uridine diphosphate glucuronosyltransferases (UGTs) are highly expressed in the liver and are involved in the metabolism of many drugs. In particular, UGT1A1 has a genetic polymorphism that causes decreased activity, leading to drug-induced hepatotoxicity. Therefore, an in vitro evaluation system th...

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Bibliographic Details
Main Authors: Tomohiro Shintani, Chiharu Imamura, Yukiko Ueyama-Toba, Jumpei Inui, Akira Watanabe, Hiroyuki Mizuguchi
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
human induced pluripotent stem cells
genome editing
hepatic organoids
drug-induced hepatotoxicity
drug metabolism
UGT1A1
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050123001171

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http://www.sciencedirect.com/science/article/pii/S2329050123001171

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