Restricted valency (NPNA) n repeats and junctional epitope-based circumsporozoite protein vaccines against Plasmodium falciparum

Restricted valency (NPNA) n repeats and junctional epitope-based circumsporozoite protein vaccines against Plasmodium falciparum

Abstract The Circumsporozoite Protein (CSP) of Plasmodium falciparum contains an N-terminal region, a conserved Region I (RI), a junctional region, 25–42 copies of major (NPNA) and minor repeats followed by a C-terminal domain. The recently approved malaria vaccine, RTS,S/AS01 contains NPNAx19 and t...

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Main Authors: Mark D. Langowski, Farhat A. Khan, Sofya Savransky, Dallas R. Brown, Arasu Balasubramaniyam, William B. Harrison, Xiaoyan Zou, Zoltan Beck, Gary R. Matyas, Jason A. Regules, Robin Miller, Lorraine A. Soisson, Adrian H. Batchelor, Sheetij Dutta
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-022-00430-y

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