Hepatocyte Small Heterodimer Partner Mediates Sex-Specific Effects on Triglyceride Metabolism via Androgen Receptor in Male Mice

Hepatocyte Small Heterodimer Partner Mediates Sex-Specific Effects on Triglyceride Metabolism via Androgen Receptor in Male Mice

Mechanisms of sex differences in hypertriglyceridemia remain poorly understood. Small heterodimer partner (SHP) is a nuclear receptor that regulates bile acid, glucose, and lipid metabolism. SHP also regulates transcriptional activity of sex hormone receptors and may mediate sex differences in trigl...

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Bibliographic Details
Main Authors: Brian T. Palmisano, Lin Zhu, Bridget Litts, Andreanna Burman, Sophia Yu, Joshua C. Neuman, Uche Anozie, Thao N. Luu, Emery M. Edington, John M. Stafford
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Metabolites
Subjects:
sex differences
hypertriglyceridemia
small heterodimer partner
postprandial TG clearance
cardiovascular disease risk
Online Access:https://www.mdpi.com/2218-1989/11/5/330

Internet

https://www.mdpi.com/2218-1989/11/5/330

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