Role of EZH2-mediated H3K27me3 in placental ADAM12-S expression: implications for fetoplacental growth

Role of EZH2-mediated H3K27me3 in placental ADAM12-S expression: implications for fetoplacental growth

Abstract Background Enhancer of zeste homolog 2 (EZH2)-mediated histone 3 lysine 27 trimethylation (H3K27me3) is a transcription silencing mark, which is indispensable for cell lineage specification at the early blastocyst stage. This epigenetic repression is maintained in placental cytotrophoblasts...

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Bibliographic Details
Main Authors: Ya-nan Zhu, Xiao-wen Gan, Fan Pan, Xiao-tian Ni, Leslie Myatt, Wang-sheng Wang, Kang Sun
Format: Article
Language:English
Published: BMC 2022-05-01
Series:BMC Medicine
Subjects:
ADAM12
EZH2
IGFBP
IGF
Placenta
Fetus
Online Access:https://doi.org/10.1186/s12916-022-02391-4

Internet

https://doi.org/10.1186/s12916-022-02391-4

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