Dual-targeting peptides@PMO, a mimetic to the pro-apoptotic protein Smac/DIABLO for selective activation of apoptosis in cancer cells

Dual-targeting peptides@PMO, a mimetic to the pro-apoptotic protein Smac/DIABLO for selective activation of apoptosis in cancer cells

The refractoriness of tumor cells to apoptosis represents the main mechanism of resistance to chemotherapy. Smac/DIABLO mimetics proved to be effective in overcoming cancer-acquired resistance to apoptosis as a consequence of overexpression of the anti-apoptotic proteins XIAP, cIAP1, and cIAP2. In t...

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Bibliographic Details
Main Authors: Eros Di Giorgio, Annalisa Ferino, Weizhe Huang, Sigrid Simonetti, Luigi Xodo, Rossella De Marco
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Pharmacology
Subjects:
Smac mimetics
nanoparticles
caspases
oxaliplatin
cervical cancer
colorectal cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1237478/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1237478/full

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