Characterization of a novel bispecific antibody targeting tissue factor-positive tumors with T cell engagement

Characterization of a novel bispecific antibody targeting tissue factor-positive tumors with T cell engagement

T cell engaging bispecific antibody (TCB) is an effective immunotherapy for cancer treatment. Through co-targeting CD3 and tumor-associated antigen (TAA), TCB can redirect CD3+ T cells to eliminate tumor cells regardless of the specificity of T cell receptor. Tissue factor (TF) is a TAA that involve...

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Bibliographic Details
Main Authors: Zhidi Pan, Jie Chen, Xiaodong Xiao, Yueqing Xie, Hua Jiang, Baohong Zhang, Huili Lu, Yunsheng Yuan, Lei Han, Yuexian Zhou, Huifang Zong, Lei Wang, Rui Sun, Jianwei Zhu
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
T cell engaging bispecific antibody
Immunotherapy
Tissue factor
Solid tumor
Pancreatic cancer
Lung cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521004317

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http://www.sciencedirect.com/science/article/pii/S2211383521004317

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