Protein language models trained on multiple sequence alignments learn phylogenetic relationships
Protein language models taking multiple sequence alignments as inputs capture protein structure and mutational effects. Here, the authors show that these models also encode phylogenetic relationships, and can disentangle correlations due to structural constraints from those due to phylogeny.
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34032-y |