A novel murine model of pyoderma gangrenosum reveals that inflammatory skin-gut crosstalk is mediated by IL-1β-primed neutrophils

A novel murine model of pyoderma gangrenosum reveals that inflammatory skin-gut crosstalk is mediated by IL-1β-primed neutrophils

Pyoderma gangrenosum (PG) is a debilitating skin condition often accompanied by inflammatory bowel disease (IBD). Strikingly, ~40% of patients that present with PG have underlying IBD, suggesting shared but unknown mechanisms of pathogenesis. Impeding the development of effective treatments for PG i...

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Bibliographic Details
Main Authors: Samreen Jatana, András K. Ponti, Erin E. Johnson, Nancy A. Rebert, Jordyn L. Smith, Clifton G. Fulmer, Edward V. Maytin, Jean-Paul Achkar, Anthony P. Fernandez, Christine McDonald
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
pyoderma gangrenosum (PG)
inflammatory bowel disease (IBD)
neutrophil extracellular traps (NETs)
neutrophilic dermatosis
skin-gut crosstalk
pyrimidine synthesis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1148893/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1148893/full

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