Efficacy of combined tumor irradiation and KCa3.1-targeting with TRAM-34 in a syngeneic glioma mouse model

Abstract The intermediate-conductance calcium-activated potassium channel KCa3.1 has been proposed to be a new potential target for glioblastoma treatment. This study analyzed the effect of combined irradiation and KCa3.1-targeting with TRAM-34 in the syngeneic, immune-competent orthotopic SMA-560/V...

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Bibliographic Details
Main Authors: Nicolai Stransky, Katrin Ganser, Leticia Quintanilla-Martinez, Irene Gonzalez-Menendez, Ulrike Naumann, Franziska Eckert, Pierre Koch, Stephan M. Huber, Peter Ruth
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-47552-4