Postinfluenza Environment Reduces Aspergillus fumigatus Conidium Clearance and Facilitates Invasive Aspergillosis In Vivo

Postinfluenza Environment Reduces Aspergillus fumigatus Conidium Clearance and Facilitates Invasive Aspergillosis In Vivo

ABSTRACT Aspergillus fumigatus is a human fungal pathogen that is most often avirulent in immunecompetent individuals because the innate immune system is efficient at eliminating fungal conidia. However, recent clinical observations have shown that severe influenza A virus (IAV) infection can lead t...

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Bibliographic Details
Main Authors: Ko-Wei Liu, Madeleine S. Grau, Jane T. Jones, Xi Wang, Elisa M. Vesely, Matthew R. James, Cecilia Gutierrez-Perez, Robert A. Cramer, Joshua J. Obar
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:mBio
Subjects:
Aspergillus fumigatus
influenza A virus
superinfection
invasive pulmonary aspergillosis
phagocytosis
phagolysosome maturation
Online Access:https://journals.asm.org/doi/10.1128/mbio.02854-22

Internet

https://journals.asm.org/doi/10.1128/mbio.02854-22

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