Recombinant Newcastle disease viruses expressing immunological checkpoint inhibitors induce a pro-inflammatory state and enhance tumor-specific immune responses in two murine models of cancer

Recombinant Newcastle disease viruses expressing immunological checkpoint inhibitors induce a pro-inflammatory state and enhance tumor-specific immune responses in two murine models of cancer

IntroductionTumor microenvironments are immunosuppressive due to progressive accumulation of mutations in cancer cells that can drive expression of a range of inhibitory ligands and cytokines, and recruitment of immunomodulatory cells, including myeloid-derived suppressor cells (MDSC), tumor-associa...

Full description

Bibliographic Details
Main Authors: Lisa A. Santry, Jacob P. van Vloten, Amanda W. K. AuYeung, Robert C. Mould, Jacob G. E. Yates, Thomas M. McAusland, James J. Petrik, Pierre P. Major, Byram W. Bridle, Sarah K. Wootton
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Microbiology
Subjects:
Newcastle disease virus (NDV)
oncolytic virus
immunological checkpoint inhibitors
anti-CTLA-4
PD-1
PD-L1
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1325558/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2024.1325558/full

Similar Items