MAPK15 controls cellular responses to oxidative stress by regulating NRF2 activity and expression of its downstream target genes

MAPK15 controls cellular responses to oxidative stress by regulating NRF2 activity and expression of its downstream target genes

Oxidation processes in mitochondria and different environmental insults contribute to unwarranted accumulation of reactive oxygen species (ROS). These, in turn, rapidly damage intracellular lipids, proteins, and DNA, ultimately causing aging and several human diseases. Cells have developed different...

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Bibliographic Details
Main Authors: Lorenzo Franci, Giulia Vallini, Franca Maria Bertolino, Vittoria Cicaloni, Giovanni Inzalaco, Mattia Cicogni, Laura Tinti, Laura Calabrese, Virginia Barone, Laura Salvini, Pietro Rubegni, Federico Galvagni, Mario Chiariello
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Redox Biology
Subjects:
Cell signaling
Chronic respiratory diseases
Cigarette smoke
Gene expression
MAP kinases
Lung cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724001071

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http://www.sciencedirect.com/science/article/pii/S2213231724001071

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