Derivation of first-order dissolution rates to estimate particle clearance and burden in the human respiratory tract
Abstract Inhalation is a portal-of-entry for aerosols via the respiratory tract where particulate burden accumulates depending on sites of particle deposition, normal clearance mechanisms, and particle solubility. The time available for dissolution of particles is determined by the balance between t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-04-01
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| Series: | Particle and Fibre Toxicology |
| Online Access: | https://doi.org/10.1186/s12989-023-00523-z |