A novel approach for large-scale manufacturing of small extracellular vesicles from bone marrow-derived mesenchymal stromal cells using a hollow fiber bioreactor

A novel approach for large-scale manufacturing of small extracellular vesicles from bone marrow-derived mesenchymal stromal cells using a hollow fiber bioreactor

Mesenchymal stromal cells (MSCs) are promising therapeutic candidates in a variety of diseases due to having immunomodulatory and pro-regenerative properties. In recent years, MSC-derived small extracellular vesicles (sEVs) have attracted increasing interest as a possible alternative to conventional...

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Bibliographic Details
Main Authors: Viktoria Jakl, Melanie Ehmele, Martina Winkelmann, Simon Ehrenberg, Tim Eiseler, Benedikt Friemert, Markus Thomas Rojewski, Hubert Schrezenmeier
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
mesenchymal stromal cells
mesenchymal stem cells
platelet lysate
hollow fiber bioreactor
exosomes
small extracellular vesicles
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1107055/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2023.1107055/full

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