The Role of Low-Dose Oral Methotrexate in Increasing Anti-TNF Drug Levels and Reducing Immunogenicity in IBD

The Role of Low-Dose Oral Methotrexate in Increasing Anti-TNF Drug Levels and Reducing Immunogenicity in IBD

Concomitant immunomodulation is utilised in combination with anti-TNF therapy for IBD primarily to increase drug levels and prevent anti-drug antibody formation. Whilst thiopurines have traditionally been the immunomodulator of choice in IBD populations, there are concerns regarding the long-term sa...

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Bibliographic Details
Main Authors: Kathryn Demase, Cassandra K. Monitto, Robert D. Little, Miles P. Sparrow
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Journal of Clinical Medicine
Subjects:
methotrexate
oral
infliximab
adalimumab
concomitant immunomodulator
pharmacokinetics
Online Access:https://www.mdpi.com/2077-0383/12/13/4382

Internet

https://www.mdpi.com/2077-0383/12/13/4382

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