Cryo-electron tomography of NLRP3-activated ASC complexes reveals organelle co-localization

Cryo-electron tomography of NLRP3-activated ASC complexes reveals organelle co-localization

Abstract NLRP3 induces caspase-1-dependent pyroptotic cell death to drive inflammation. Aberrant activity of NLRP3 occurs in many human diseases. NLRP3 activation induces ASC polymerization into a single, micron-scale perinuclear punctum. Higher resolution imaging of this signaling platform is neede...

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Bibliographic Details
Main Authors: Yangci Liu, Haoming Zhai, Helen Alemayehu, Jérôme Boulanger, Lee J. Hopkins, Alicia C. Borgeaud, Christina Heroven, Jonathan D. Howe, Kendra E. Leigh, Clare E. Bryant, Yorgo Modis
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43180-8

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https://doi.org/10.1038/s41467-023-43180-8

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