Insights into the complex formed by matrix metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations.

Insights into the complex formed by matrix metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations.

Matrix metalloproteinases (MMP) are well-known biological targets implicated in tumour progression, homeostatic regulation, innate immunity, impaired delivery of pro-apoptotic ligands, and the release and cleavage of cell-surface receptors. Hence, the development of potent and selective inhibitors t...

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Bibliographic Details
Main Authors: Ilenia Giangreco, Gianluca Lattanzi, Orazio Nicolotti, Marco Catto, Antonio Laghezza, Francesco Leonetti, Angela Stefanachi, Angelo Carotti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3187794?pdf=render

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http://europepmc.org/articles/PMC3187794?pdf=render

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