Inhibition of TRIF-Dependent Inflammation Decelerates Afterload-Induced Myocardial Remodeling

Inhibition of TRIF-Dependent Inflammation Decelerates Afterload-Induced Myocardial Remodeling

Pressure-overload-induced cardiac hypertrophy represents one cause of the development of heart failure. The aim of this study is to characterize the influence of the TIR-domain-containing adapter-inducing interferon-β (TRIF) during afterload-induced myocardial remodeling. After trans-aortic constric...

Full description

Bibliographic Details
Main Authors:	Stephanie I. Bettink, Jan-Christian Reil, Andrey Kazakov, Christina Körbel, Dominic Millenaar, Ulrich Laufs, Bruno Scheller, Michael Böhm, Stephan H. Schirmer
Format:	Article
Language:	English
Published:	MDPI AG 2022-10-01
Series:	Biomedicines
Subjects:	TRIF fibrosis hypertrophy inflammation afterload
Online Access:	https://www.mdpi.com/2227-9059/10/10/2636

Similar Items

Different activation of MAPKs and Akt/GSK3β after preload vs. afterload elevation
by: Nico Hartmann, et al.
Published: (2022-06-01)

Myocardial Afterload Is a Key Biomechanical Regulator of Atrioventricular Myocyte Differentiation in Zebrafish
by: Neha Ahuja, et al.
Published: (2022-01-01)

A case of afterload mismatch associated with shivering leading to fetal hypoxia in a COVID-19 patient
by: Takanori Suzuka, et al.
Published: (2022-07-01)

Kidney cell culture of Rana dybowskii and study molecules of TRIF in Rana dybowskii cells under the stress of Aeromonas hydrophila
by: B. Wang, et al.
Published: (2023-12-01)

The RHIM of the Immune Adaptor Protein TRIF Forms Hybrid Amyloids with Other Necroptosis-Associated Proteins
by: Max O. D. G. Baker, et al.
Published: (2022-05-01)

The rate of force generation by the myocardium is not influenced by afterload
by: Fioretto J.R., et al.
Published: (1997-01-01)

Effects of artemisinin on ventricular arrhythmias in response to left ventricular afterload increase and microRNA expression profiles in Wistar rats
by: Xue Xu, et al.
Published: (2018-12-01)

Right Ventricular Strain by Magnetic Resonance Feature Tracking Is Largely Afterload-Dependent and Does Not Reflect Contractility: Validation by Combined Volumetry and Invasive Pressure Tracings
by: Andreas Rolf, et al.
Published: (2022-12-01)

Gynecological brachytherapy with Elekta microSelectron V3 afterloading system
by: Kornhuber Christine, et al.
Published: (2017-09-01)

Sensitivity of ventricular systolic function to afterload during veno‐arterial extracorporeal membrane oxygenation
by: Pauline Yeung Ng, et al.
Published: (2022-10-01)

TRIF-dependent signaling and its role in liver diseases
by: Lilin Hu, et al.
Published: (2024-04-01)

High Right Ventricular Afterload during Exercise in Patients with Pulmonary Arterial Hypertension
by: Mari Nishizaki, et al.
Published: (2021-05-01)

Cyprinus carpio TRIF Participates in the Innate Immune Response by Inducing NF-κB and IFN Activation and Promoting Apoptosis
by: Rongrong Liu, et al.
Published: (2021-08-01)

IRF3 Negatively Regulates Toll-Like Receptor-Mediated NF-κB Signaling by Targeting TRIF for Degradation in Teleost Fish
by: Xueyan Zhao, et al.
Published: (2018-04-01)

Pathogenic Leptospires Limit Dendritic Cell Activation Through Avoidance of TLR4 and TRIF Signaling
by: Julie Cagliero, et al.
Published: (2022-06-01)

Microglial TIR-domain-containing adapter-inducing interferon-β (TRIF) deficiency promotes retinal ganglion cell survival and axon regeneration via nuclear factor-κB
by: Lin Sen, et al.
Published: (2012-02-01)

SARM suppresses TRIF, TRAF3, and IRF3/7 mediated antiviral signaling in large yellow croaker Larimichthys crocea
by: Jia Xi Zhang, et al.
Published: (2023-01-01)

MicroRNA-181b-2 and MicroRNA-21-1 Negatively Regulate NF-κB and IRF3-Mediated Innate Immune Responses via Targeting TRIF in Teleost
by: Yuena Sun, et al.
Published: (2021-12-01)

Down-regulation of TLR2, 3, 9 and Signaling Mediators, MyD88 and TRIF, Gene Transcript Levels in Patients with Kawasaki Disease Treated with IVIG
by: Seyed Hamidreza Mortazavi, et al.
Published: (2015-04-01)

Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage
by: Lin Sen, et al.
Published: (2012-03-01)

Novel Findings in Teleost TRAF4, a Protein Acts as an Enhancer in TRIF and TRAF6 Mediated Antiviral and Inflammatory Signaling
by: Ying Chen, et al.
Published: (2022-07-01)

TIR Domain-Containing Adaptor-Inducing Interferon-β (TRIF) Participates in Antiviral Immune Responses and Hepatic Lipogenesis of Large Yellow Croaker (Larimichthys Crocea)
by: Si Zhu, et al.
Published: (2019-10-01)

Prognostic Value of Right Ventricular Afterload in Patients Undergoing Mitral Transcatheter Edge‐to‐Edge Repair
by: Rody G. Bou Chaaya, et al.
Published: (2024-04-01)

Impaired Left Ventricular Circumferential Midwall Systolic Performance Appears Linked to Depressed Preload, but Not Intrinsic Contractile Dysfunction or Excessive Afterload, in Paradoxical Low-Flow/Low-Gradient Severe Aortic Stenosis
by: Dorota Długosz, et al.
Published: (2022-05-01)

Afterload reduction after non-invasive vagus nerve stimulation in acute heart failure
by: Michiaki Nagai, et al.
Published: (2023-03-01)

Exercise and pulsatile pulmonary vascular loading in chronic thromboembolic pulmonary disease
by: Sinan Osman, et al.
Published: (2024-01-01)

RIP3 Associates with RIP1, TRIF, MAVS, and Also IRF3/7 in Host Innate Immune Signaling in Large Yellow Croaker <i>Larimichthys crocea</i>
by: Pengfei Zou, et al.
Published: (2021-10-01)

Palmitic Acid Promotes Lung Metastasis of Melanomas via the TLR4/TRIF-Peli1-pNF-κB Pathway
by: Xuedan Zhang, et al.
Published: (2022-11-01)

P.68 WaveGraft–A Novel Endovascular Device Concept for Restoring the Natural Arterial Cushioning Effect
by: Florian Stefanov, et al.
Published: (2020-12-01)

The Th1/Tfh-like biased responses elicited by the rASP-1 innate adjuvant are dependent on TRIF and Type I IFN receptor pathways
by: Parakkal Jovvian George, et al.
Published: (2022-09-01)

Impact of pressure recovery on the assessment of pulmonary homograft function using Doppler ultrasound
by: Jan‐Christian Reil, et al.
Published: (2022-12-01)

Systemic activation of TLR3-dependent TRIF signaling confers host defense against Gram-negative bacteria in the intestine
by: Jose eRuiz, et al.
Published: (2016-01-01)

The role of TRIF protein in regulating the proliferation and antigen presentation ability of myeloid dendritic cells through the ERK1/2 signaling pathway in chronic low-grade inflammation of intestinal mucosa mediated by flagellin-TLR5 complex signal
by: Zhaomeng Zhuang, et al.
Published: (2024-01-01)

Surface immunogenic protein from Streptococcus agalactiae and Fissurella latimarginata hemocyanin are TLR4 ligands and activate MyD88- and TRIF dependent signaling pathways
by: Diego A. Díaz-Dinamarca, et al.
Published: (2023-09-01)

Advanced echocardiographic phenotyping of critically ill patients with coronavirus-19 sepsis: a prospective cohort study
by: François Bagate, et al.
Published: (2021-01-01)

Blood pressure changes during routine transthoracic echocardiography
by: Mazhar Kadwalwala, et al.
Published: (2023-03-01)

Renal failure in critically ill patients, beware of applying (central venous) pressure on the kidney
by: Xiukai Chen, et al.
Published: (2018-09-01)

Preventive Mechanism of Lycopene on Intestinal Toxicity Caused by Cyclophosphamide Chemotherapy in Mice by Regulating TLR4-MyD88/TRIF-TRAF6 Signaling Pathway and Gut-Liver Axis
by: Xiao Pan, et al.
Published: (2022-10-01)

A genome-wide search of Toll/Interleukin-1 receptor (TIR) domain-containing adapter molecule (TICAM) and their evolutionary divergence from other TIR domain containing proteins
by: Shailya Verma, et al.
Published: (2022-09-01)

Induction and Suppression of Innate Antiviral Responses by Hepatitis A Virus
by: Xin Cao, et al.
Published: (2018-08-01)