Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase

Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase

Lipocalin prostaglandin D synthase (L-PGDS) regulates synthesis of an important inflammatory and signaling mediator, prostaglandin D2 (PGD2). Here, we used structural, biophysical, and biochemical approaches to address the mechanistic aspects of substrate entry, catalysis, and product exit of this e...

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Detalhes bibliográficos
Principais autores: Sing Mei Lim, Dan Chen, Hsiangling Teo, Annette Roos, Anna Elisabet Jansson, Tomas Nyman, Lionel Trésaugues, Konstantin Pervushin, Pär Nordlund
Formato: Artigo
Idioma:English
Publicado em: Elsevier 2013-06-01
coleção:Journal of Lipid Research
Assuntos:
lipid signaling
X-ray crystallography
nuclear magnetic resonance spectroscopy
lipophilic substrate
protein-lipid interaction
β trace protein
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0022227520357199

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http://www.sciencedirect.com/science/article/pii/S0022227520357199

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