Proteomic analysis of HDL from inbred mouse strains implicates APOE associated with HDL in reduced cholesterol efflux capacity via the ABCA1 pathway[S]

Proteomic analysis of HDL from inbred mouse strains implicates APOE associated with HDL in reduced cholesterol efflux capacity via the ABCA1 pathway[S]

Cholesterol efflux capacity associates strongly and negatively with the incidence and prevalence of human CVD. We investigated the relationships of HDL's size and protein cargo with its cholesterol efflux capacity using APOB-depleted serum and HDLs isolated from five inbred mouse strains with d...

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Bibliographic Details
Main Authors: Nathalie Pamir, Patrick Hutchins, Graziella Ronsein, Tomas Vaisar, Catherine A. Reardon, Godfrey S. Getz, Aldons J. Lusis, Jay W. Heinecke
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Journal of Lipid Research
Subjects:
atherosclerosis
cardiovascular risk
mass spectrometry
high density lipoprotein
apolipoprotein E
ATP binding cassette transporter A1
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520354602

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http://www.sciencedirect.com/science/article/pii/S0022227520354602

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