Targeting met mediated epithelial‐mesenchymal transition in the treatment of breast cancer

Abstract Mesenchymal epithelial transition factor receptor (Met) is a receptor tyrosine kinase that plays a critical role in promoting cancer cell malignant progression. Met is activated by its ligand hepatocyte growth factor (HGF). HGF‐dependent Met activation plays an important role in stimulating...

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Bibliographic Details
Main Author: Paul W Sylvester
Format: Article
Language:English
Published: Wiley 2014-12-01
Series:Clinical and Translational Medicine
Subjects:
Online Access:https://doi.org/10.1186/s40169-014-0030-5