Efficient Intravenous Tumor Targeting Using the αvβ6 Integrin-Selective Precision Virotherapy Ad5<sub>NULL</sub>-A20

Efficient Intravenous Tumor Targeting Using the αvβ6 Integrin-Selective Precision Virotherapy Ad5<sub>NULL</sub>-A20

We previously developed a refined, tumor-selective adenovirus, Ad5<sub>NULL</sub>-A20, harboring tropism ablating mutations in each major capsid protein, to ablate all native means of infection. We incorporated a 20-mer peptide (A20) in the fiber knob for selective infection via αvβ6 int...

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Bibliographic Details
Main Authors: James A. Davies, Gareth Marlow, Hanni K. Uusi-Kerttula, Gillian Seaton, Luke Piggott, Luned M. Badder, Richard W. E. Clarkson, John D. Chester, Alan L. Parker
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Viruses
Subjects:
adenovirus
oncolytic
virotherapy
targeting
αvβ6 integrin
systemic delivery
Online Access:https://www.mdpi.com/1999-4915/13/5/864

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https://www.mdpi.com/1999-4915/13/5/864

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