The net electrostatic potential and hydration of ABCG2 affect substrate transport

The net electrostatic potential and hydration of ABCG2 affect substrate transport

Abstract ABCG2 is a medically important ATP-binding cassette transporter with crucial roles in the absorption and distribution of chemically-diverse toxins and drugs, reducing the cellular accumulation of chemotherapeutic drugs to facilitate multidrug resistance in cancer. ABCG2’s capacity to transp...

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Bibliographic Details
Main Authors: Tomoka Gose, Heather M. Aitken, Yao Wang, John Lynch, Evadnie Rampersaud, Yu Fukuda, Medb Wills, Stefanie A. Baril, Robert C. Ford, Anang Shelat, Megan L. O’ Mara, John D. Schuetz
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40610-5

Internet

https://doi.org/10.1038/s41467-023-40610-5

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