Neutrophils Lose the Capacity to Suppress T Cell Proliferation Upon Migration Towards Inflamed Joints in Juvenile Idiopathic Arthritis

Neutrophils Lose the Capacity to Suppress T Cell Proliferation Upon Migration Towards Inflamed Joints in Juvenile Idiopathic Arthritis

Neutrophils are highly abundant in synovial fluid of rheumatic inflamed joints. In oligoarticular juvenile idiopathic arthritis (JIA), synovial fluid neutrophils have impaired effector functions and altered phenotype. We hypothesized that these alterations might impact the immunoregulatory interplay...

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Bibliographic Details
Main Authors: Sabine Arve-Butler, Anki Mossberg, Tobias Schmidt, Charlotte Welinder, Hong Yan, Elisabet Berthold, Petra Król, Robin Kahn
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
neutrophil
T cell
juvenile idiopathic arthritis
suppression
reactive oxygen species
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.795260/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.795260/full

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