Pharmacokinetic comparison of sitagliptin and metformin HCl extended-release tablets versus JANUMET® XR in healthy volunteers under fasting and fed conditions

Pharmacokinetic comparison of sitagliptin and metformin HCl extended-release tablets versus JANUMET® XR in healthy volunteers under fasting and fed conditions

Background and Objectives: Janumet® XR is the combination of sitagliptin and extended metformin hydrochloride produced by Merck Sharp & Dohme. It is specially designed for diabetes mellitus patients taking both drugs already. Janumet® XR exhibited clinically significant blood glucose lowerin...

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Bibliographic Details
Main Authors: Linling Que, Wei Qin, Yunfei Shi, Ying Ding, Kai Huang, Zhenzhong Qian, Bingjie Huang, Peipei Zhou, Qing He
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
sitagliptin
metformin
Janumet® XR
diabetes
bioequivalence
pharmacokinetics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1105767/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1105767/full

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