Repurposing Antidepressants and Phenothiazine Antipsychotics as Efflux Pump Inhibitors in Cancer and Infectious Diseases

Repurposing Antidepressants and Phenothiazine Antipsychotics as Efflux Pump Inhibitors in Cancer and Infectious Diseases

Multidrug resistance (MDR) is a major obstacle in the therapy of infectious diseases and cancer. One of the major mechanisms of MDR is the overexpression of efflux pumps (EPs) that are responsible for extruding antimicrobial and anticancer agents. EPs have additional roles of detoxification that may...

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Bibliographic Details
Main Authors: Bálint Rácz, Gabriella Spengler
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Antibiotics
Subjects:
drug repurposing
MDR efflux pumps
multidrug resistance
antidepressant
antipsychotic
selective serotonin reuptake inhibitors (SSRIs)
Online Access:https://www.mdpi.com/2079-6382/12/1/137

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https://www.mdpi.com/2079-6382/12/1/137

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