The double-edged sword of (re)expression of genes by hypomethylating agents: from viral mimicry to exploitation as priming agents for targeted immune checkpoint modulation

The double-edged sword of (re)expression of genes by hypomethylating agents: from viral mimicry to exploitation as priming agents for targeted immune checkpoint modulation

Abstract Hypomethylating agents (HMAs) have been widely used over the last decade, approved for use in myelodysplastic syndrome (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML). The proposed central mechanism of action of HMAs, is the reversal of aberrant methylation in...

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Bibliographic Details
Main Authors: Florian Wolff, Michael Leisch, Richard Greil, Angela Risch, Lisa Pleyer
Format: Article
Language:English
Published: BMC 2017-03-01
Series:Cell Communication and Signaling
Subjects:
DNA methylation
Tumor microenvironment
Hypomethylating agents
Endogenous retroviral elements
Immune checkpoint blockade
Immune checkpoint inhibitors
Online Access:http://link.springer.com/article/10.1186/s12964-017-0168-z

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http://link.springer.com/article/10.1186/s12964-017-0168-z

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