Lack of an association between clinical INSTI-related body weight gain and direct interference with MC4 receptor (MC4R), a key central regulator of body weight.

Lack of an association between clinical INSTI-related body weight gain and direct interference with MC4 receptor (MC4R), a key central regulator of body weight.

An increasing prevalence of overweight and obesity in people living with HIV has been associated with initiation of antiretroviral therapy with integrase strand transfer inhibitors (INSTIs). An off-target inhibition of the endogenous ligand binding to the human melanocortin 4 receptor (MC4R) has bee...

Full description

Bibliographic Details
Main Authors: Carrie McMahon, James L Trevaskis, Christoph Carter, Kevin Holsapple, Kirsten White, Moupali Das, Sean Collins, Hal Martin, Leigh Ann Burns-Naas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0229617

Internet

https://doi.org/10.1371/journal.pone.0229617

Similar Items