Design and synthesis of novel hydroxamic acid derivatives based on quisinostat as promising antimalarial agents with improved safety
In our previous work, the clinical phase II HDAC inhibitor quisinostat was identified as a promising antimalarial agent through a drug repurposing strategy, but its safety was a matter of concern. Herein, further medicinal chemistry methods were used to identify new chemical entities with greater ef...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Compuscript Ltd
2022-05-01
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| Series: | Acta Materia Medica |
| Subjects: | |
| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2022-0007 |