N-terminally truncated Aβ4-x proteoforms and their relevance for Alzheimer’s pathophysiology

N-terminally truncated Aβ4-x proteoforms and their relevance for Alzheimer’s pathophysiology

Abstract Background The molecular heterogeneity of Alzheimer’s amyloid-β (Aβ) deposits extends well beyond the classic Aβ1-40/Aβ1-42 dichotomy, substantially expanded by multiple post-translational modifications that increase the proteome diversity. Numerous truncated fragments consistently populate...

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Bibliographic Details
Main Authors: Agueda Rostagno, Erwin Cabrera, Tammaryn Lashley, Jorge Ghiso
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Translational Neurodegeneration
Subjects:
Alzheimer’s disease
Amyloid-β truncated species
Peptide oligomerization
Brain clearance
Brain efflux
Stereotaxic intracerebral injection
Online Access:https://doi.org/10.1186/s40035-022-00303-3

Internet

https://doi.org/10.1186/s40035-022-00303-3

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