Microfluidic Bi-Layer Platform to Study Functional Interaction between Co-Cultured Neural Networks with Unidirectional Synaptic Connectivity

Microfluidic Bi-Layer Platform to Study Functional Interaction between Co-Cultured Neural Networks with Unidirectional Synaptic Connectivity

The complex synaptic connectivity architecture of neuronal networks underlies cognition and brain function. However, studying the spiking activity propagation and processing in heterogeneous networks in vivo poses significant challenges. In this study, we present a novel two-layer PDMS chip that fac...

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Bibliographic Details
Main Authors: Yana Pigareva, Arseniy Gladkov, Vladimir Kolpakov, Anton Bukatin, Sergei Li, Victor B. Kazantsev, Irina Mukhina, Alexey Pimashkin
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Micromachines
Subjects:
microfluidics
neuronal tissue engineering
organ-on-a-chip
microfluidic cell culture
drug discovery
coculture techniques
Online Access:https://www.mdpi.com/2072-666X/14/4/835

Internet

https://www.mdpi.com/2072-666X/14/4/835

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