7,8,15,16-tetraoxa-dispiro[5.2.5.2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity

Several C2 symmetrical mixed tetraoxanes were prepared starting from a gemdihydroperoxide and a ketone. The obtained tetraoxanes showed pronounced antimalarial activity against P. falciparum chloroquine resistant W2 and chloroquine susceptible D6 strains, with N-(2-dimethylamino)ethyl-7,8,15,16-tetr...

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Bibliographic Details
Main Authors: BOGDAN SOLAJA, WILBUR K. MILHOUS, DEJAN OPSENICA, NATASA TERZIC, IGOR OPSENICA
Format: Article
Language:English
Published: Serbian Chemical Society 2004-11-01
Series:Journal of the Serbian Chemical Society
Subjects:
Online Access:http://www.shd.org.yu/HtDocs/SHD/Vol69/No11/V69-No11-11.pdf