2-Acetamido-2-deoxy-<span style="font-variant: small-caps">d</span>-glucono-1,5-lactone Sulfonylhydrazones: Synthesis and Evaluation as Inhibitors of Human OGA and HexB Enzymes

2-Acetamido-2-deoxy-<span style="font-variant: small-caps">d</span>-glucono-1,5-lactone Sulfonylhydrazones: Synthesis and Evaluation as Inhibitors of Human OGA and HexB Enzymes

Inhibition of the human <i>O</i>-linked β-<i>N</i>-acetylglucosaminidase (hOGA, GH84) enzyme is pharmacologically relevant in several diseases such as neurodegenerative and cardiovascular disorders, type 2 diabetes, and cancer. Human lysosomal hexosaminidases (hHexA and hHexB...

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Bibliographic Details
Main Authors: Mariann Kiss, István Timári, Teréz Barna, Zuzana Mészáros, Kristýna Slámová, Pavla Bojarová, Vladimír Křen, Joseph M. Hayes, László Somsák
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
hOGA
hHexB
inhibitor
glyconolactone sulfonylhydrazone
Prime refinement
QM/MM optimization
Online Access:https://www.mdpi.com/1422-0067/23/3/1037

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https://www.mdpi.com/1422-0067/23/3/1037

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