Exposed and Sequestered Antigens in Testes and Their Protection by Regulatory T Cell-Dependent Systemic Tolerance

Exposed and Sequestered Antigens in Testes and Their Protection by Regulatory T Cell-Dependent Systemic Tolerance

Continuous exposure of tissue antigen (Ag) to the autoantigen-specific regulatory T cells (Treg) is required to maintain Treg-dependent systemic tolerance. Thus, testis autoantigens, previously considered as sequestered, may not be protected by systemic tolerance. We now document that the complete t...

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Bibliographic Details
Main Authors: Jessica Harakal, Hui Qiao, Karen Wheeler, Claudia Rival, Alberta G. A. Paul, Daniel M. Hardy, C. Yan Cheng, Erwin Goldberg, Kenneth S. K. Tung
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
testis autoantigens and autoantibodies
exposed and sequestered testis autoantigens
the residual bodies and cytoplasmic droplets
experimental and human autoimmune orchitis
post-vasectomy tolerance versus orchitis
Foxp3+ regulatory T cells and systemic tolerance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.809247/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.809247/full

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